Cymbalta Quick Facts

Cymbalta is an antidepressant in the SNRI (selective serotonin-norepinephrine reuptake inhibitor) class.

Other Brand Names: none
Generic Name: Duloxetine

Primary Uses:

  • Major Depressive Disorder
  • Generalized Anxiety Disorder
  • Stress Urinary Incontinence (Europe only)

Other Uses:

  • Diabetic Neuropathy
  • Fibromyalgia

Availability: 20mg, 30mg, 60mg capsules

Contraindications:

  • Any known hypersensitivity to Cymbalta
  • Concurrent use of MAOI’s
  • Uncontrolled narrow-angle glaucoma
  • Concurrent use of other CNS-acting drugs
  • Concurrent use of thioridazine

Side Effects:

  • Nausea (34.7%)
  • Dry Mouth (22.7%)
  • Headache (20.0%)
  • Dizziness (18.7%)
  • Rash (rare)

Black Box Warnings:may increase the risk of suicide in persons younger than 25.

Metabolized: Liver
Excreted: Urine (70%), Feces (20%)
Half-life: 12.1 Hours

Withdrawal Effects:

  • Dysphoric mood
  • Irritability
  • Agitation
  • Dizziness
  • Brain zaps
  • Anxiety
  • Tiredness
  • Headache
  • Confusion
  • Mood Swings
  • Insomnia
  • Hypomania
  • Tinnitus
  • Seizures

Cymbalta should be tapered slowly to avoid withdrawal effects. Frequency of withdrawal effects are unknown.

Source: Wikipedia

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