Prometrium Quick Facts

Prometrium (Progesterone) is a “bioidentical” hormone in the progestin class of hormones. Unlike other progestin sources, the bioidentical term indicates that the progestin used is structurally identical to human progesterone. Prometrium is a plant derived progesterone suspended in peanut oil in a capsule. Prometrium is micronized Progesterone suspended in peanut oil.

Brand Names: Prometrium

Generic Names: Micronized Progesterone in Peanut Oil

Primary Uses:

  • Hormone Replacement Therapy for menopausal women
  • Restarting of menstrual cycle for those who have previously had them, but have stopped having them

Other Uses:

  • Hormone Therapy in male assigned at birth transgender and gender non-conforming individuals (Off Label Usage)


  • 100 mg capsule
  • 200 mg capsule


  • Allergies to any ingredients including peanuts
  • If you are or may be pregnant, trying to become pregnant, or breast feeding
  • Abnormal vaginal bleeding
  • Have or have had certain cancers
  • If you have had heart problems, strokes, or liver problems

Side Effects:

Common Side Effects:

  • Dizziness
  • Abdominal pain (cramping)
  • Headache
  • Breast tenderness/pain
  • Musculoskeletal pain
  • Viral infection
  • Depression
  • Urinary problems
  • Abdominal bloating
  • Vaginal discharge

More Serious Side Effects:

  • Chest pain, shortness of breath
  • Severe headache
  • Difficulty speaking or walking
  • Breast pain or feel a lump in your breast
  • Confusion and memory problems

Withdrawal Effects:

Not Applicable

Additional Information:

Prometrium may dramatically increase the risk of heart disease, strokes, and clotting. Talk to your doctor about this risk as it pertains to you.

While not a psychiatric medication, Prometrium and other progestins, as well as other hormones including estrogen and testosterone may have a powerful effect on your mood and mental health. Prometrium and other bioidentical micronized progesterones (generics) may have fewer negative side effects as compared to lab created progestins. Consult your doctor for their opinion. If you have existing mental health conditions or take any psychiatric medications, please consult your prescribing psychiatrist and keep them informed.


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