Risperdal Quick Facts

Risperdal is a second-generation antipsychotic. It works by reducing dopamine, serotonin and norepinephrine levels in the brain.

Generic Name: Risperidone

Primary Uses:

  • Schizophrenia
  • Bipolar Disorder

Other Uses:

  • Schizoaffective Disorder
  • Autism
  • Treatment-resistant depression
  • Anxiety disorders
  • Obsessive-Compulsive Disorder
  • Eating disorders
  • Tourette’s Syndrome

Availability: 0.25mg, 0.5mg, 1mg, 2mg, 3mg and 4mg oral tablets, 0.5mg, 1mg, 2mg, 3mg, 4mg sublingual tablets. Also available is Risperdal Consta, an intramuscular injection which is given every 2 weeks.

Contraindications: 

  • Liver or kidney disease
  • Heart rhythm problems
  • High cholesterol or triglycerides
  • Past heart attacks or strokes
  • Past breast cancer
  • Epilepsy or seizures
  • Diabetes
  • Suicidal thoughts
  • Parkinson’s disease
  • Trouble swallowing

Side Effects:

  • Weight gain
  • Akathesia
  • Sedation
  • Dysphoria
  • Insomnia
  • Elevated prolactin levels
  • Low blood pressure
  • High blood pressure
  • Muscle stiffness or pain
  • Tremors
  • Hypersalivation
  • Constipation
  • Runny nose
  • Lactation
  • Photosensitivity

Serious Side Effects:

  • Neuroleptic malignant syndrome
  • Extrapyramidal symptoms
  • Tardive dyskinesia

Black Box Warnings: Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.

Metabolization: Liver
Excretion: Urinary
Half-Life: 20 hours

Withdrawal Effects: Risperdal should be tapered down slowly to avoid any rebound psychosis or withdrawal effects. Withdrawal effects include insomnia, lightheadedness, rapid heart rate, dyskinesia, nervousness, dizziness, headache, non-stop crying, and anxiety.

Sources:

http://en.wikipedia.org/wiki/Risperidone

http://www.drugs.com/risperidone.html

http://www.rxlist.com/risperdal-drug.htm

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